Nvidia Profits Soar, Soothing Investor Jitters Over AI Boom (5 minute read) Nvidia reported record sales at its quarterly earnings report yesterday. The company hit a record $57 billion in the October quarter, up 62% from the year-earlier quarter. Nvidia estimates sales for the current quarter will reach $65 billion. Shares in the company rose up to 6.5% in after-hours trading. | | Science & Futuristic Technology | Aging as a disease: The rise of longevity science (13 minute read) The frontier of medicine is shifting from fighting disease to pursuing more life. Speakers at the recent Progress Conference 2025 held at Lighthaven spoke about extending life by addressing the biological hallmarks of aging itself: genomic instability, telomere shortening, mitochondrial dysfunction, and cellular senescence. The new frontier is to find targeted interventions that impact these factors. The pursuit of longevity, not survival, is still in its early days. Research is happening largely along non-traditional paths and with non-traditional funding and support models. | New nanoparticle mRNA vaccine may be cheaper and 100 times more powerful (3 minute read) Researchers at MIT have developed a new lipid nanoparticle that enhances the effectiveness of an mRNA vaccine by a hundred times compared to stand-alone effectiveness in mice. The system could be used to develop vaccines for a number of diseases, including COVID-19 and influenza. By increasing potency and reducing cost per dosage, the system could become an inexpensive way to combat many infectious diseases. It could also help improve the efficacy of some vaccines. | | Programming, Design & Data Science | Building more with GPT-5.1-Codex-Max (8 minute read) GPT‑5.1-Codex-Max is a new frontier agentic coding model from OpenAI. It is much faster, more intelligent, and more token-efficient at every stage of the development cycle. The model is built for long-running, detailed work. It is available in Codex today. API access is coming soon. | Pyrefly (GitHub Repo) Pyrefly is a type checker and language server for Python that provides lightning-fast type checking and IDE features. It can infer types in most locations and understand a program's control flow to refine static types. Pyrefly aims for large-scale incrementality at the module level. It is under active development with known issues. | | Companies Are Warming Up to Saying AI Is the Reason for Job Cuts (8 minute read) AI was referenced in roughly a fifth of total job cuts announced in the US last month. Executives have been touting efficiency gains from AI as a reason for a shrinking or flat workforce. Even when companies aren't saying AI helps eliminate jobs, they are mentioning it as a reason to raise the bar on new hires. There is still some uncertainty about how useful AI tools are and how to fit them into daily work - if tech firms can ease that uncertainty, it may open the door to wider corporate AI adoption. | The FTC's Meta Antitrust Implosion (5 minute read) Meta worked to make Instagram and WhatsApp successful by improving their design and increasing their revenue. The company has been forced to evolve in response to competition, increasing smartphone usage, and a massive leap in AI-powered algorithms. To prove that Meta holds a monopoly would require proving that TikTok, YouTube, Reddit, and X aren't real competitors. Meta's enormous profits aren't evidence of monopoly power. | | Mojo-V (GitHub Repo) Mojo-V is a new RISC-V extension that implements secret computation, enabling secure, efficient, and data-oblivious execution. | | | Want to advertise in TLDR? š° If your company is interested in reaching an audience of tech executives, decision-makers and engineers, you may want to advertise with us. Want to work at TLDR? š¼ Apply here or send a friend's resume to jobs@tldr.tech and get $1k if we hire them! If you have any comments or feedback, just respond to this email! Thanks for reading, Dan Ni & Stephen Flanders | | | |
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